This is wrong not completely right. IF you are having RAM from 16K to 48K then you are nearly right. Pokemon showed a method of running machine code above 48K without any modification if you respect BIT 6. This gives you only half the opcodes but still very useful for programs which will be developed soon . You could call a zeddy a RISC machine above 48K (Reduced Instruction Set Computer)
Here you go even moggy EVERYBODY is able to run programs above 48K and without any software tricks there can still be data there like games levels etc.
And IF you select CONFIG M=L then there is always some RAM missing between 40K and 48K where it could be useful.
By the way, did I mention MIDI MIDI MIDI MIDI MIDI MIDI MIDI already?